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    This is a "high-risk game"

    This is a “high-risk game”

    A hospital in Paris was forced to cancel surgery to transfer patients due to cyberattacks

    A hospital in Paris was forced to cancel surgery to transfer patients due to cyberattacks

    Musk shouted at Bezos: If you want to dominate the space race, spend less time bathing in hot water

    Musk shouted at Bezos: If you want to dominate the space race, spend less time bathing in hot water

    How lucky are Indian children in the United States to get out of a "boarding school" alive?

    How lucky are Indian children in the United States to get out of a “boarding school” alive?

    Japanese billionaires broadcast live in space, saying the next stop is Mariana Trench

    Japanese billionaires broadcast live in space, saying the next stop is Mariana Trench

    Want to go to Mars? Solve these problems first.

    Want to go to Mars? Solve these problems first.

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    This is a "high-risk game"

    This is a “high-risk game”

    The government recruits "rat control chiefs" with high salaries in New York, USA

    The government recruits “rat control chiefs” with high salaries in New York, USA

    San Francisco "allows mechanical police to kill people" and Pandora's magic box opened

    San Francisco “allows mechanical police to kill people” and Pandora’s magic box opened

    Asia’s first star was online rioted by South Korean netizens

    Asia’s first star was online rioted by South Korean netizens

    scoring two goals in 90 seconds, Real Madrid "resurreated" in the Champions League to the finals

    scoring two goals in 90 seconds, Real Madrid “resurreated” in the Champions League to the finals

    Schedule of the 2024 Paris Olympic Games announced

    Schedule of the 2024 Paris Olympic Games announced

    Secretary-General of the Qatar World Cup Organizing Committee: Welcome to Qatar

    Secretary-General of the Qatar World Cup Organizing Committee: Welcome to Qatar

    Chinese women's football team competes in the 2022 Indian Women's Football Asian Cup

    Chinese women’s football team competes in the 2022 Indian Women’s Football Asian Cup

    Djokovic issued a statement: Extremely disappointed with the judgment of the Australian court

    Djokovic issued a statement: Extremely disappointed with the judgment of the Australian court

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    This is a "high-risk game"

    This is a “high-risk game”

    A hospital in Paris was forced to cancel surgery to transfer patients due to cyberattacks

    A hospital in Paris was forced to cancel surgery to transfer patients due to cyberattacks

    The government recruits "rat control chiefs" with high salaries in New York, USA

    The government recruits “rat control chiefs” with high salaries in New York, USA

    The United States reported 180 cases of hepatitis in children with unknown causes, spreading to 36 states and territories.

    The United States reported 180 cases of hepatitis in children with unknown causes, spreading to 36 states and territories.

    8 cases of hepatitis in children with unknown causes were found in Argentina

    8 cases of hepatitis in children with unknown causes were found in Argentina

    Students in many parts of the United States went on strike to protest against the severity of the school epidemic and asked officials to take practical measures to prevent the epidemic

    Students in many parts of the United States went on strike to protest against the severity of the school epidemic and asked officials to take practical measures to prevent the epidemic

    Belgian fighting champion dies of COVID-19: Refuses to go to hospital before death, saying that COVID-19 is just a small virus

    Belgian fighting champion dies of COVID-19: Refuses to go to hospital before death, saying that COVID-19 is just a small virus

    With the increasing number of confirmed cases of COVID-19, the Indian capital New Delhi will impose a curfew on the 27th.

    With the increasing number of confirmed cases of COVID-19, the Indian capital New Delhi will impose a curfew on the 27th.

    255 U.S. personnel have been diagnosed with a cluster infection in U.S. military camps in Okinawa Prefecture, Japan

    255 U.S. personnel have been diagnosed with a cluster infection in U.S. military camps in Okinawa Prefecture, Japan

    Israeli Prime Minister Bennett is quarantined due to his daughter's diagnosis of COVID-19

    Israeli Prime Minister Bennett is quarantined due to his daughter’s diagnosis of COVID-19

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      This is a "high-risk game"

      This is a “high-risk game”

      A hospital in Paris was forced to cancel surgery to transfer patients due to cyberattacks

      A hospital in Paris was forced to cancel surgery to transfer patients due to cyberattacks

      Musk shouted at Bezos: If you want to dominate the space race, spend less time bathing in hot water

      Musk shouted at Bezos: If you want to dominate the space race, spend less time bathing in hot water

      How lucky are Indian children in the United States to get out of a "boarding school" alive?

      How lucky are Indian children in the United States to get out of a “boarding school” alive?

      Japanese billionaires broadcast live in space, saying the next stop is Mariana Trench

      Japanese billionaires broadcast live in space, saying the next stop is Mariana Trench

      Want to go to Mars? Solve these problems first.

      Want to go to Mars? Solve these problems first.

      Trending Tags

      • Google
      • Apple
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      • Science & Technology
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      This is a "high-risk game"

      This is a “high-risk game”

      The government recruits "rat control chiefs" with high salaries in New York, USA

      The government recruits “rat control chiefs” with high salaries in New York, USA

      San Francisco "allows mechanical police to kill people" and Pandora's magic box opened

      San Francisco “allows mechanical police to kill people” and Pandora’s magic box opened

      Asia’s first star was online rioted by South Korean netizens

      Asia’s first star was online rioted by South Korean netizens

      scoring two goals in 90 seconds, Real Madrid "resurreated" in the Champions League to the finals

      scoring two goals in 90 seconds, Real Madrid “resurreated” in the Champions League to the finals

      Schedule of the 2024 Paris Olympic Games announced

      Schedule of the 2024 Paris Olympic Games announced

      Secretary-General of the Qatar World Cup Organizing Committee: Welcome to Qatar

      Secretary-General of the Qatar World Cup Organizing Committee: Welcome to Qatar

      Chinese women's football team competes in the 2022 Indian Women's Football Asian Cup

      Chinese women’s football team competes in the 2022 Indian Women’s Football Asian Cup

      Djokovic issued a statement: Extremely disappointed with the judgment of the Australian court

      Djokovic issued a statement: Extremely disappointed with the judgment of the Australian court

    • Lifestyle
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      This is a "high-risk game"

      This is a “high-risk game”

      A hospital in Paris was forced to cancel surgery to transfer patients due to cyberattacks

      A hospital in Paris was forced to cancel surgery to transfer patients due to cyberattacks

      The government recruits "rat control chiefs" with high salaries in New York, USA

      The government recruits “rat control chiefs” with high salaries in New York, USA

      The United States reported 180 cases of hepatitis in children with unknown causes, spreading to 36 states and territories.

      The United States reported 180 cases of hepatitis in children with unknown causes, spreading to 36 states and territories.

      8 cases of hepatitis in children with unknown causes were found in Argentina

      8 cases of hepatitis in children with unknown causes were found in Argentina

      Students in many parts of the United States went on strike to protest against the severity of the school epidemic and asked officials to take practical measures to prevent the epidemic

      Students in many parts of the United States went on strike to protest against the severity of the school epidemic and asked officials to take practical measures to prevent the epidemic

      Belgian fighting champion dies of COVID-19: Refuses to go to hospital before death, saying that COVID-19 is just a small virus

      Belgian fighting champion dies of COVID-19: Refuses to go to hospital before death, saying that COVID-19 is just a small virus

      With the increasing number of confirmed cases of COVID-19, the Indian capital New Delhi will impose a curfew on the 27th.

      With the increasing number of confirmed cases of COVID-19, the Indian capital New Delhi will impose a curfew on the 27th.

      255 U.S. personnel have been diagnosed with a cluster infection in U.S. military camps in Okinawa Prefecture, Japan

      255 U.S. personnel have been diagnosed with a cluster infection in U.S. military camps in Okinawa Prefecture, Japan

      Israeli Prime Minister Bennett is quarantined due to his daughter's diagnosis of COVID-19

      Israeli Prime Minister Bennett is quarantined due to his daughter’s diagnosis of COVID-19

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      What are the challenges in the development of coronavirus drugs to fight against viral variants virus?

      January 22, 2021
      in Health
      0
      New Zealand appeared in the coronavirus variant found in the UK, and Oakland was completely blockaded for 3 days.

      The German Confederation and the state governments reached an agreement on the 19th to extend the main coronavirus prevention measures to February 14. The picture shows a warning sign that reminds people to wear masks in Rome Square, Frankfurt, Germany, on January 20. Photo by Xinhua News Agency reporter Qi Yang

      Recently, a variety of variant COVID-19 has appeared in South Africa, the United Kingdom and even Germany, causing a surge in infections in these countries.

      Some scientists say that variants appearing in the United Kingdom and South Africa allow the novel coronavirus to avoid immune responses, which may lead to the reduction of the effectiveness of certain antibody drugs.

      The website of The Wall Street Journal recently reported that in view of this, some pharmaceutical companies are stepping up the development of a new generation of COVID-19 drugs to fight the variant’s of the virus.

      Virus variant’s challenges antibody therapy

      Recently, the emergence of COVID-19 variants named B.1.1.7 and 501Y.V2 in the United Kingdom and South Africa respectively has attracted great attention.

      In addition, the German Bavarian Broadcasting Corporation reported on January 18 that Bavaria has found a variant novel coronavirus different from the previous occurrences in the United Kingdom and South Africa.

      These strains are more capable of transmitting than previous strains. Even if these strains are not more lethal, they may further burden the health care system.

      Moreover, the more people infected with the virus, the more likely it is to variant, which may reduce the effectiveness of existing drugs.

      Former FDA chief Scott Gottlieb said in an earlier interview that the 501Y.V2 coronavirus variant is worrying because it seems to invalidate certain medical countermeasures, especially antibody drugs.

      “The discovery of the variant of COVID-19 in South Africa is worrying and may pose a threat to existing antibody treatments for the novel coronavirus,” Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, told CNBC.

      Experts say that although there is no evidence that COVID-19 variant will affect the efficacy of existing vaccines, these variants may still reduce the effectiveness of monoclonal antibody drugs, according to the CNBC website.

       “Vaccines trigger immune responses that attack different parts of the virus, but monoclonal antibodies only target specific parts of the virus,” Fauci said.

      In a report on January 13, CNBC’s website pointed out that Dave Ricks, CEO of Eli Lilly, said that the variant found in South Africa may invalidate an antibody drug produced by the company.

      Eli Lilly’s antibody drug developed against COVID-19 was authorized by the FDA for emergency use in November 2020.

      Ricks said that the COVID-19 variant worried them because of the large variants in the spine protein of the virus strain.

      “The spine protein is exactly the target of antibody drugs, so in theory, this variant can avoid the attack of antibody drugs.”

      “Cocktail” drugs are less affected

      However, the Wall Street Journal reported that Jesse Bloom, an associate professor and biologist at the Fred Hutchinson Cancer Research Center in the United States, said that another drug authorized by the FDA should still be effective because it was produced by Regenerative Yuan Pharmaceutical Company of the United States, which combines cocktail drugs with two different antibodies. , only one of the antibodies was affected by 501Y.V2.

      “From the beginning, we’ve sought ‘cocktail’ therapy, and if there is a variation, there’s still an effective drug,” said Crystal Kiratsu, vice president of infectious disease and viral vector technology research at Regenerative Metapharma.

      Regenerative Yuan Pharmaceuticals says its drugs seem to be effective against British variants.

      The company is also developing more “cocktail drugs” to deal with future viral variant’s that may become drug-resistant to its drugs.

      A spokesman for Eli Lilly said that the drug bamlanivimab produced by the company can completely fight against variant strains found in the UK in laboratory tests.

      But independent scientists said they could not confirm the effectiveness of the drug, because Eli Lilly had not yet released the genetic sequence of the antibody.

      Image Source: Visual China

      “Generalized neutralization” antibodies are favored

      In a report, the Wall Street Journal pointed out that researchers are developing “generally neutralizing” antibodies due to the anticipation of drug-resistant virus variant‘s. 

      They believe that this antibody can effectively fight against many different coronavirus variants.

      Adi Mabu received $130 million in venture capital and plans to start a clinical trial of drugs this month.

      The drug could be authorized as soon as the third quarter, the company said.

      Coincidentally, Valve Biotechnology Co., Ltd. and GlaxoSmithKline in the United Kingdom are also cooperating to test an antibody drug.

      They hope that even if there is a new variant of the novel coronavirus, the antibody drug will still work.

      Most antibody drugs can only prevent the virus from entering new cells, but they develop antibodies that activate other immune systems to attack the virus after the virus infects the cell, explained George Scangos, CEO of Vil Biotechnology.

      The devil is one foot taller, and the road is ten feet taller! The coronavirus is constantly changing, and the struggle between human beings and it is also a race against time.

      Tags: coronaCovid-19Pandemic

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      Five people were killed in a fire at the Indian Serum Research Institute. Prime Minister Modi sent a message to mourn.

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      The cumulative number of confirmed cases exceeds 24 million. The United States has implemented stricter "mask orders".

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